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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC2
All Species:
55.15
Human Site:
S182
Identified Species:
75.83
UniProt:
P06493
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P06493
NP_001777.1
297
34081
S182
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
Chimpanzee
Pan troglodytes
XP_001164618
264
30384
F153
D
F
G
L
A
R
A
F
G
I
P
I
R
V
Y
Rhesus Macaque
Macaca mulatta
XP_001095798
297
34077
S182
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
Dog
Lupus familis
XP_849450
297
34047
S182
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
Cat
Felis silvestris
Mouse
Mus musculus
P11440
297
34088
S182
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
Rat
Rattus norvegicus
P39951
297
34116
S182
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509674
303
34737
S182
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
Chicken
Gallus gallus
P13863
303
34670
S182
L
L
G
S
A
L
Y
S
T
P
V
D
I
W
S
Frog
Xenopus laevis
P24033
302
34513
S182
L
L
G
S
V
R
Y
S
T
P
V
D
V
W
S
Zebra Danio
Brachydanio rerio
NP_997729
302
34539
S182
L
L
G
A
S
R
Y
S
T
P
V
D
L
W
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P23572
297
34420
S182
L
L
G
S
P
R
Y
S
C
P
V
D
I
W
S
Honey Bee
Apis mellifera
XP_393093
585
68394
S469
L
L
G
A
N
R
Y
S
C
A
I
D
I
W
S
Nematode Worm
Caenorhab. elegans
P34556
332
38277
S200
L
M
G
A
Q
R
Y
S
M
G
V
D
M
W
S
Sea Urchin
Strong. purpuratus
XP_781415
301
34665
A181
L
L
G
S
T
R
Y
A
C
P
I
D
M
W
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
S182
L
L
G
A
R
Q
Y
S
T
P
V
D
V
W
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
S182
L
L
G
S
H
H
Y
S
T
P
V
D
I
W
S
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
K187
P
E
V
L
L
G
G
K
Q
Y
S
T
G
V
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88.5
99.3
98.6
N.A.
96.3
96.9
N.A.
95.3
90.4
84.7
81.4
N.A.
71.3
36.2
58.4
70.1
Protein Similarity:
100
88.8
99.6
99.6
N.A.
98.6
98.9
N.A.
96.6
94.3
93.3
91.7
N.A.
83.8
42.2
72.8
86.7
P-Site Identity:
100
20
100
100
N.A.
100
100
N.A.
100
93.3
86.6
80
N.A.
86.6
66.6
60
66.6
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
100
93.3
93.3
100
N.A.
86.6
80
80
86.6
Percent
Protein Identity:
N.A.
63.3
N.A.
64.9
59
N.A.
Protein Similarity:
N.A.
78.7
N.A.
79.4
76.5
N.A.
P-Site Identity:
N.A.
73.3
N.A.
86.6
0
N.A.
P-Site Similarity:
N.A.
93.3
N.A.
86.6
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
24
48
0
6
6
0
6
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
18
0
0
0
0
0
0
% C
% Asp:
6
0
0
0
0
0
0
0
0
0
0
89
0
0
6
% D
% Glu:
0
6
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
6
0
0
0
0
0
6
0
0
0
0
0
0
0
% F
% Gly:
0
0
95
0
0
6
6
0
6
6
0
0
6
0
0
% G
% His:
0
0
0
0
6
6
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
6
12
6
59
0
0
% I
% Lys:
0
0
0
0
0
0
0
6
0
0
0
0
0
0
0
% K
% Leu:
89
83
0
12
6
6
0
0
0
0
0
0
6
0
0
% L
% Met:
0
6
0
0
0
0
0
0
6
0
0
0
12
0
0
% M
% Asn:
0
0
0
0
6
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
6
0
0
0
6
0
0
0
0
77
6
0
0
0
0
% P
% Gln:
0
0
0
0
6
6
0
0
6
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
6
77
0
0
0
0
0
0
6
0
0
% R
% Ser:
0
0
0
65
6
0
0
83
0
0
6
0
0
0
89
% S
% Thr:
0
0
0
0
6
0
0
0
65
0
0
6
0
0
0
% T
% Val:
0
0
6
0
6
0
0
0
0
0
77
0
12
12
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
89
0
% W
% Tyr:
0
0
0
0
0
0
89
0
0
6
0
0
0
0
6
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _